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Poxviral-based vaccine elicits immunologic responses in prostate cancer patients.


ABSTRACT: Prostvac is a poxviral-based vaccine designed to target prostate-specific antigen (PSA) in prostate cancer patients. Recently, the potential toxicity and immunological impact of this immunotherapy were reviewed in the context of new clinical data. Our findings suggest that Prostvac is safe and elicits anticancer immune responses, both alone and in combinatorial approaches.

SUBMITTER: Madan RA 

PROVIDER: S-EPMC4091323 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Poxviral-based vaccine elicits immunologic responses in prostate cancer patients.

Madan Ravi A RA   Heery Christopher R CR   Gulley James L JL  

Oncoimmunology 20140429


Prostvac is a poxviral-based vaccine designed to target prostate-specific antigen (PSA) in prostate cancer patients. Recently, the potential toxicity and immunological impact of this immunotherapy were reviewed in the context of new clinical data. Our findings suggest that Prostvac is safe and elicits anticancer immune responses, both alone and in combinatorial approaches. ...[more]

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