Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer.
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ABSTRACT:
SUBMITTER: Morales-Kastresana A
PROVIDER: S-EPMC4091451 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer.
Morales-Kastresana Aizea A Labiano Sara S Gütgemann Ines I Melero Ignacio I
Oncoimmunology 20140116
Immunostimulatory monoclonal antibodies can be given in combinations, hence modulating the activity of 2 or more receptors of the immune system. Some of these combinations have been shown to synergize at the elicitation of therapeutically relevant immune responses in transgenic mice developing spontaneous, oncogene-driven tumors, including multifocal hepatocellular carcinomas expressing ovalbumin as a surrogate tumor-associated antigen. ...[more]
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