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Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer.

ABSTRACT: Immunostimulatory monoclonal antibodies can be given in combinations, hence modulating the activity of 2 or more receptors of the immune system. Some of these combinations have been shown to synergize at the elicitation of therapeutically relevant immune responses in transgenic mice developing spontaneous, oncogene-driven tumors, including multifocal hepatocellular carcinomas expressing ovalbumin as a surrogate tumor-associated antigen.

SUBMITTER: Morales-Kastresana A 

PROVIDER: S-EPMC4091451 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer.

Morales-Kastresana Aizea A   Labiano Sara S   Gütgemann Ines I   Melero Ignacio I  

Oncoimmunology 20140116

Immunostimulatory monoclonal antibodies can be given in combinations, hence modulating the activity of 2 or more receptors of the immune system. Some of these combinations have been shown to synergize at the elicitation of therapeutically relevant immune responses in transgenic mice developing spontaneous, oncogene-driven tumors, including multifocal hepatocellular carcinomas expressing ovalbumin as a surrogate tumor-associated antigen. ...[more]

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