Ontology highlight
ABSTRACT:
SUBMITTER: Andries K
PROVIDER: S-EPMC4092087 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Andries Koen K Villellas Cristina C Coeck Nele N Thys Kim K Gevers Tom T Vranckx Luc L Lounis Nacer N de Jong Bouke C BC Koul Anil A
PloS one 20140710 7
Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multi-drug resistant tuberculosis in decades. In vitro resistance to BDQ was previously shown to be due to target-based mutations. Here we report that non-target based resistance to BDQ, and cross-resistance to clofazimine (CFZ), is due to mutations in Rv0678, a transcriptional repressor of the genes encoding the MmpS5-MmpL5 efflux pump. Efflux-based resistance was identified in paired isolates from p ...[more]