Inhibition of human dyskerin as a new approach to target ribosome biogenesis.

ABSTRACT: The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting these cellular processes has been explored for the development of drugs to selectively or preferentially kill cancer cells. Presently, intense research is conducted involving the identification of new biological targets whose modulation may simultaneously interfere with multiple cellular functions that are known to be hyper-activated by neoplastic transformations. Here, we report, for the first time, the computational identification of small molecules able to inhibit dyskerin catalytic activity. Different in silico techniques were applied to select compounds and analyze the binding modes and the interaction patterns of ligands in the human dyskerin catalytic site

SUBMITTER: Rocchi L 

PROVIDER: S-EPMC4092089 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature