A new role for human dyskerin in vesicular trafficking.
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ABSTRACT:
SUBMITTER: Di Maio N
PROVIDER: S-EPMC5623704 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
A new role for human dyskerin in vesicular trafficking.
Di Maio Nunzia N Vicidomini Rosario R Angrisani Alberto A Belli Valentina V Furia Maria M Turano Mimmo M
FEBS open bio 20170912 10
Dyskerin is an essential, conserved, multifunctional protein found in the nucleolus, whose loss of function causes the rare genetic diseases X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. To further investigate the wide range of dyskerin's biological roles, we set up stable cell lines able to trigger inducible protein knockdown and allow a detailed analysis of the cascade of events occurring within a short time frame. We report that dyskerin depletion quickly induces cytoskel ...[more]
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