Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
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ABSTRACT:
SUBMITTER: Minois N
PROVIDER: S-EPMC4092136 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
Minois Nadège N Rockenfeller Patrick P Smith Terry K TK Carmona-Gutierrez Didac D
PloS one 20140710 7
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, ...[more]
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