Ontology highlight
ABSTRACT:
SUBMITTER: Zhou JJ
PROVIDER: S-EPMC4094037 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Zhou Jie J JJ Wang Feng F Xu Zhiwen Z Lo Wing-Sze WS Lau Ching-Fun CF Chiang Kyle P KP Nangle Leslie A LA Ashlock Melissa A MA Mendlein John D JD Yang Xiang-Lei XL Zhang Mingjie M Schimmel Paul P
The Journal of biological chemistry 20140604 28
Inflammatory and debilitating myositis and interstitial lung disease are commonly associated with autoantibodies (anti-Jo-1 antibodies) to cytoplasmic histidyl-tRNA synthetase (HisRS). Anti-Jo-1 antibodies from different disease-afflicted patients react mostly with spatially separated epitopes in the three-dimensional structure of human HisRS. We noted that two HisRS splice variants (SVs) include these spatially separated regions, but each SV lacks the HisRS catalytic domain. Despite the large d ...[more]