Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC4094295 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130131 6126
Receptor-interacting protein kinase 4 (RIPK4) is required for epidermal differentiation and is mutated in Bartsocas-Papas syndrome. RIPK4 binds to protein kinase C, but its signaling mechanisms are largely unknown. Ectopic RIPK4, but not catalytically inactive or Bartsocas-Papas RIPK4 mutants, induced accumulation of cytosolic β-catenin and a transcriptional program similar to that caused by Wnt3a. In Xenopus embryos, Ripk4 synergized with coexpressed Xwnt8, whereas Ripk4 morpholinos or catalyti ...[more]