Ontology highlight
ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC5328672 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Zeng Xin X Huang He H Tamai Keiko K Zhang Xinjun X Harada Yuko Y Yokota Chika C Almeida Karla K Wang Jianbo J Doble Brad B Woodgett Jim J Wynshaw-Boris Anthony A Hsieh Jen-Chieh JC He Xi X
Development (Cambridge, England) 20071212 2
Canonical Wnt/beta-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3) initiates Wnt/beta-catenin signaling. Here we show that both Fz and Dvl ...[more]