Ontology highlight
ABSTRACT:
SUBMITTER: Okumura K
PROVIDER: S-EPMC4094504 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Okumura Kazuhiro K Saito Megumi M Isogai Eriko E Aoto Yoshimasa Y Hachiya Tsuyoshi T Sakakibara Yasubumi Y Katsuragi Yoshinori Y Hirose Satoshi S Kominami Ryo R Goitsuka Ryo R Nakamura Takuro T Wakabayashi Yuichi Y
PloS one 20140711 7
Previous studies have shown that Meis1 plays an important role in blood development and vascular homeostasis, and can induce blood cancers, such as leukemia. However, its role in epithelia remains largely unknown. Here, we uncover two roles for Meis1 in the epidermis: as a critical regulator of epidermal homeostasis in normal tissues and as a proto-oncogenic factor in neoplastic tissues. In normal epidermis, we show that Meis1 is predominantly expressed in the bulge region of the hair follicles ...[more]