Ontology highlight
ABSTRACT:
SUBMITTER: Clingman CC
PROVIDER: S-EPMC4094780 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Clingman Carina C CC Deveau Laura M LM Hay Samantha A SA Genga Ryan M RM Shandilya Shivender M D SM Massi Francesca F Ryder Sean P SP
eLife 20140616
Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for their function. Pluripotent stem cells have the ability to differentiate into a wide variety of specialized cells. How metabolic state contributes to stem cell differentiation is not understood. In this study, we show that RNA-binding by the stem cell translation regulator Musashi-1 (MSI1) is allosteri ...[more]