Ontology highlight
ABSTRACT:
SUBMITTER: Conde-Jaldon M
PROVIDER: S-EPMC4096596 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Conde-Jaldón Marta M Montes-Cano Marco Antonio MA García-Lozano José Raul JR Ortiz-Fernández Lourdes L Ortego-Centeno Norberto N González-León Rocío R Espinosa Gerard G Graña-Gil Genaro G Sánchez-Bursón Juan J González-Gay Miguel Angel MA Barnosi-Marín Ana Celia AC Solans Roser R Fanlo Patricia P Carballeira Mónica Rodríguez MR Camps Teresa T Castañeda Santos S Martín Javier J González-Escribano María Francisca MF
PloS one 20140714 7
Behçet's disease (BD) is a multifactorial disorder associated with the HLA region. Recently, the ERAP1 gene has been proposed as a susceptibility locus with a recessive model and with epistatic interaction with HLA-B51. ERAP1 trims peptides in the endoplasmic reticulum to optimize their length for MHC-I binding. Polymorphisms in this gene have been related with the susceptibility to other immune-mediated diseases associated to HLA class I. Our aim was, the replication in the Spanish population o ...[more]