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Injectable bioadhesive hydrogels with innate antibacterial properties.


ABSTRACT: Surgical site infections cause significant postoperative morbidity and increased healthcare costs. Bioadhesives used to fill surgical voids and support wound healing are typically devoid of antibacterial activity. Here we report novel syringe-injectable bioadhesive hydrogels with inherent antibacterial properties prepared from mixing polydextran aldehyde and branched polyethylenimine. These adhesives kill both Gram-negative and Gram-positive bacteria, while sparing human erythrocytes. An optimal composition of 2.5?wt% oxidized dextran and 6.9?wt% polyethylenimine sets within seconds forming a mechanically rigid (~1,700?Pa) gel offering a maximum adhesive stress of ~2.8?kPa. A murine infection model showed that the adhesive is capable of killing Streptococcus pyogenes introduced subcutaneously at the bioadhesive's surface, with minimal inflammatory response. The adhesive was also effective in a cecal ligation and puncture model, preventing sepsis and significantly improving survival. These bioadhesives represent novel, inherently antibacterial materials for wound-filling applications.

SUBMITTER: Giano MC 

PROVIDER: S-EPMC4096704 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Injectable bioadhesive hydrogels with innate antibacterial properties.

Giano Michael C MC   Ibrahim Zuhaib Z   Medina Scott H SH   Sarhane Karim A KA   Christensen Joani M JM   Yamada Yuji Y   Brandacher Gerald G   Schneider Joel P JP  

Nature communications 20140624


Surgical site infections cause significant postoperative morbidity and increased healthcare costs. Bioadhesives used to fill surgical voids and support wound healing are typically devoid of antibacterial activity. Here we report novel syringe-injectable bioadhesive hydrogels with inherent antibacterial properties prepared from mixing polydextran aldehyde and branched polyethylenimine. These adhesives kill both Gram-negative and Gram-positive bacteria, while sparing human erythrocytes. An optimal  ...[more]

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