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Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.

ABSTRACT: Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.

SUBMITTER: Yesilyurt V

PROVIDER: S-EPMC4825176 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.

Yesilyurt Volkan V Webber Matthew J MJ Appel Eric A EA Godwin Colin C Langer Robert R Anderson Daniel G DG

Advanced materials (Deerfield Beach, Fla.) 20151105 1

Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo. ...[more]

PMID: 26540021

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