Halogenated diarylacetylenes repress c-myc expression in cancer cells.
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ABSTRACT:
SUBMITTER: Sviripa VM
PROVIDER: S-EPMC4096707 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Halogenated diarylacetylenes repress c-myc expression in cancer cells.
Sviripa Vitaliy M VM Zhang Wen W Kril Liliia M LM Liu Alice X AX Yuan Yaxia Y Zhan Chang-Guo CG Liu Chunming C Watt David S DS
Bioorganic & medicinal chemistry letters 20140509 15
Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents. ...[more]
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