Ontology highlight
ABSTRACT:
SUBMITTER: Fowler T
PROVIDER: S-EPMC3900694 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Fowler Trent T Ghatak Payel P Price David H DH Conaway Ronald R Conaway Joan J Chiang Cheng-Ming CM Bradner James E JE Shilatifard Ali A Roy Ananda L AL
PloS one 20140123 1
High level MYC expression is associated with almost all human cancers. JQ1, a chemical compound that inhibits MYC expression is therapeutically effective in preclinical animal models in midline carcinoma, and Burkitt's lymphoma (BL). Here we show that JQ1 does not inhibit MYC expression to a similar extent in all tumor cells. The BL cells showed a ∼90% decrease in MYC transcription upon treatment with JQ1, however, no corresponding reduction was seen in several non-BL cells. Molecularly, these d ...[more]