Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.
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ABSTRACT:
SUBMITTER: Rabinovitch M
PROVIDER: S-EPMC4097142 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.
Rabinovitch Marlene M Guignabert Christophe C Humbert Marc M Nicolls Mark R MR
Circulation research 20140601 1
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arterial hypertension that could form a biomarker platform are discussed. Pre-clinical studies that provide the basis for dysregulated immunity in animal models of the disease are reviewed. In addition, we present therapies that target inflammatory/immune ...[more]
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