Ontology highlight
ABSTRACT:
SUBMITTER: Guignabert C
PROVIDER: S-EPMC9639182 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Guignabert Christophe C Tu Ly L Le Hiress Morane M Ricard Nicolas N Sattler Caroline C Seferian Andrei A Huertas Alice A Humbert Marc M Montani David D
European respiratory review : an official journal of the European Respiratory Society 20131201 130
Although the causal pathomechanisms contributing to remodelling of the pulmonary vascular bed in pulmonary arterial hypertension (PAH) are still unclear, several analogous features with carcinogenesis have led to the emergence of the cancer-like concept. The major similarities concern the altered crosstalk between cells from different tissue types, unexplained proliferation and survival of pulmonary smooth muscle and endothelial cells, the metabolic (glycolytic) shifts, and the association with ...[more]