Unknown

Dataset Information

0

Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?


ABSTRACT: Earlier reports indicated that patients with the apolipoprotein APOE ε4 allele responded to fish oil supplementation with a rise in serum low-density lipoprotein cholesterol (LDL-C) compared to ε3 homozygotes. In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Data from 136,701 patients were available to compare lipid biomarker levels across Omega-3 Index categories associated with heart disease risk in all APOE genotypes. We found no adverse interactions between APOE genotype and the Omega-3 Index for LDL-C, LDL particle number, apoB, HDL-C, or triglycerides. However, we did find evidence that ε2 homozygotes lack an association between omega-3 status and LDL-C, apoB, and LDL particle number. In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.

SUBMITTER: Harris WS 

PROVIDER: S-EPMC4098055 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7052223 | biostudies-literature
2013-02-05 | E-GEOD-39140 | biostudies-arrayexpress
2013-02-05 | GSE39140 | GEO
| S-EPMC6003211 | biostudies-literature
| S-EPMC3554747 | biostudies-literature
| S-EPMC3657737 | biostudies-literature
| S-EPMC8484638 | biostudies-literature
| S-EPMC6097058 | biostudies-literature
| S-EPMC3943463 | biostudies-literature
| S-EPMC8411851 | biostudies-literature