Ontology highlight
ABSTRACT:
SUBMITTER: Bessede A
PROVIDER: S-EPMC4098076 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nature 20140701 7508
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) ...[more]