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Total syntheses of secalonic acids?A and D.

ABSTRACT: Total syntheses of the dimeric tetrahydroxanthone natural products secalonic acids?A and D are described. Key steps involve kinetic resolution of the tetrahydroxanthone core structure using homobenzotetramisole catalysis and late-stage copper(I)-mediated homodimerization of complex aryl stannane monomers.

SUBMITTER: Qin T

PROVIDER: S-EPMC4098722 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Total syntheses of secalonic acids A and D.

Qin Tian T Porco John A JA

Angewandte Chemie (International ed. in English) 20140212 12

Total syntheses of the dimeric tetrahydroxanthone natural products secalonic acids A and D are described. Key steps involve kinetic resolution of the tetrahydroxanthone core structure using homobenzotetramisole catalysis and late-stage copper(I)-mediated homodimerization of complex aryl stannane monomers. ...[more]

PMID: 24519991

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