Ontology highlight
ABSTRACT:
SUBMITTER: Liang A
PROVIDER: S-EPMC4099362 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Liang Aiye A Thakkar Jay N JN Hindle Michael M Desai Umesh R UR
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121002
Sulfated low molecular weight lignins (LMWLs), a mixture of chemo-enzymatically prepared oligomers, have been found to be potent antagonists of coagulation. However, structures that induce anticoagulation remain unidentified. The highly polar sulfate groups on these molecules and the thousands of different structures present in these mixtures make traditional chromatographic resolution of sulfated LMWLs difficult. We performed dynamic thrombin affinity chromatography monitored using chromogenic ...[more]