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Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography.

ABSTRACT: The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.

SUBMITTER: Mazzoccanti G

PROVIDER: S-EPMC9051050 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography.

Mazzoccanti Giulia G Manetto Simone S Bassan Michele M Foschini Alberto A Orlandin Andrea A Ricci Antonio A Cabri Walter W Ismail Omar H OH Catani Martina M Cavazzini Alberto A Gasparrini Francesco F

RSC advances 20200327 21

The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market. ...[more]

PMID: 35497586

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