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Predicting treatment failure in patients with community acquired pneumonia: a case-control study.


ABSTRACT: INTRODUCTION: Treatment failure in community-acquired-pneumonia (CAP) patients is associated with a high mortality rate, and therefore are a matter of great concern in clinical management. Those patients have increased mortality and are a target population for randomized clinical trials. METHODS: A case-control study was performed in patients with CAP (non-failure cases vs. failure cases, discriminating by late and early failure). CRP, PCT, interleukin 1, 6, 8 and 10 and TNF were determined at days 1 and 3 of hospitalization. RESULTS: A total of 253 patients were included in this study where 83 patients presented treatment failure. Of these, 40 (48.2%) had early failure. A discriminative effect was found for a higher CURB-65 score among late failure patients (p =?0.004). A significant increase on day 1 of hospitalization in CRP (p

SUBMITTER: Martin-Loeches I 

PROVIDER: S-EPMC4099489 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Predicting treatment failure in patients with community acquired pneumonia: a case-control study.

Martin-Loeches Ignacio I   Valles Xavier X   Menendez Rosario R   Sibila Oriol O   Montull Beatriz B   Cilloniz Catia C   Artigas Antonio A   Torres Antoni A  

Respiratory research 20140705


<h4>Introduction</h4>Treatment failure in community-acquired-pneumonia (CAP) patients is associated with a high mortality rate, and therefore are a matter of great concern in clinical management. Those patients have increased mortality and are a target population for randomized clinical trials.<h4>Methods</h4>A case-control study was performed in patients with CAP (non-failure cases vs. failure cases, discriminating by late and early failure). CRP, PCT, interleukin 1, 6, 8 and 10 and TNF were de  ...[more]

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