Ontology highlight
ABSTRACT:
SUBMITTER: Sedgewick AE
PROVIDER: S-EPMC4100606 | biostudies-literature | 2008 Nov-Dec
REPOSITORIES: biostudies-literature
Blood cells, molecules & diseases 20080808 3
Increased HbF levels or F-cell (HbF containing erythrocyte) numbers can ameliorate the disease severity of beta-thalassemia major and sickle cell anemia. Recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in BCL11A gene on chromosome 2p16.1 were correlated with F-cells among healthy northern Europeans, and HbF among Sardinians with beta-thalassemias. In this study, we showed that SNPs in BCL11A were associated with F-cell numbers in Chinese with beta-thal ...[more]