Ontology highlight
ABSTRACT:
SUBMITTER: Kaitsuka T
PROVIDER: S-EPMC4101474 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Kaitsuka Taku T Katagiri Chiaki C Beesetty Pavani P Nakamura Kenji K Hourani Siham S Tomizawa Kazuhito K Kozak J Ashot JA Matsushita Masayuki M
Scientific reports 20140717
Transient receptor potential (TRP) family channels are involved in sensory pathways and respond to various environmental stimuli. Among the members of this family, TRPM7 is a unique fusion of an ion channel and a C-terminus kinase domain that is highly expressed in immune cells. TRPM7 serves as a key molecule governing cellular Mg(2+) homeostasis in mammals since its channel pore is permeable to Mg(2+) ions and can act as a Mg(2+) influx pathway. However, mechanistic links between its kinase act ...[more]