Ontology highlight
ABSTRACT:
SUBMITTER: Camps J
PROVIDER: S-EPMC4101663 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Camps Jordi J Wangsa Darawalee D Falke Martin M Brown Markus M Case Chanelle M CM Erdos Michael R MR Ried Thomas T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140414 8
Nuclear lamin B1 (LMNB1) constitutes one of the major structural proteins in the lamina mesh. We silenced the expression of LMNB1 by RNA interference in the colon cancer cell line DLD-1 and showed a dramatic redistribution of H3K27me3 from the periphery to a more homogeneous nuclear dispersion. In addition, we observed telomere attrition and an increased frequency of micronuclei and nuclear blebs. By 3D-FISH analyses, we demonstrated that the volume and surface of chromosome territories were sig ...[more]