Ontology highlight
ABSTRACT:
SUBMITTER: Cheng CW
PROVIDER: S-EPMC4102383 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Cheng Chia-Wei CW Adams Gregor B GB Perin Laura L Wei Min M Zhou Xiaoying X Lam Ben S BS Da Sacco Stefano S Mirisola Mario M Quinn David I DI Dorff Tanya B TB Kopchick John J JJ Longo Valter D VD
Cell stem cell 20140601 6
Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloi ...[more]