Ontology highlight
ABSTRACT:
SUBMITTER: Petersen BS
PROVIDER: S-EPMC4102722 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Petersen Britt-Sabina BS Spehlmann Martina E ME Raedler Andreas A Stade Björn B Thomsen Ingo I Rabionet Raquel R Rosenstiel Philip P Schreiber Stefan S Franke Andre A
BMC genomics 20140705
<h4>Background</h4>Crohn's disease (CD) is an inflammatory bowel disease caused by genetic and environmental factors. More than 160 susceptibility loci have been identified for IBD, yet a large part of the genetic variance remains unexplained. Recent studies have demonstrated genetic differences between monozygotic twins, who were long thought to be genetically completely identical.<h4>Results</h4>We aimed to test if somatic mutations play a role in CD etiology by sequencing the genomes and exom ...[more]