Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC5729853 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Xu Yuejuan Y Li Tingting T Pu Tian T Cao Ruixue R Long Fei F Chen Sun S Sun Kun K Xu Rang R
Twin research and human genetics : the official journal of the International Society for Twin Studies 20171201 6
Congenital heart disease (CHD) is one of the most common birth defects. More than 200 susceptibility loci have been identified for CHDs, yet a large part of the genetic risk factors remain unexplained. Monozygotic (MZ) twins are thought to be completely genetically identical; however, discordant phenotypes have been found in MZ twins. Recent studies have demonstrated genetic differences between MZ twins. We aimed to test whether copy number variants (CNVs) and/or genetic mutation differences pla ...[more]