Ontology highlight
ABSTRACT:
SUBMITTER: Turner JP
PROVIDER: S-EPMC4102963 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Turner J Phillip JP Lutz-Rechtin Tammy T Moore Kelly A KA Rogers Lauren L Bhave Omkar O Moss Melissa A MA Servoss Shannon L SL
ACS chemical neuroscience 20140416 7
Alzheimer's disease (AD) is the most common form of dementia and the sixth leading cause of death in the United States. Plaques composed of aggregated amyloid-beta protein (Aβ) accumulate between the neural cells in the brain and are associated with dementia and cellular death. Many strategies have been investigated to prevent Aβ self-assembly into disease-associated β-sheet amyloid aggregates; however, a promising therapeutic has not yet been identified. In this study, a peptoid-based mimic of ...[more]