Ontology highlight
ABSTRACT:
SUBMITTER: Luo Y
PROVIDER: S-EPMC3689191 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Luo Yuan Y Vali Sheetal S Sun Suya S Chen Xuesong X Liang Xia X Drozhzhina Tatiana T Popugaeva Elena E Bezprozvanny Ilya I
ACS chemical neuroscience 20130307 6
Alzheimer's disease (AD) is the most common form of dementia and currently affects 5.4 million Americans. A number of anti-Aβ (beta amyloid) therapeutic agents have been developed for AD, but so far all of them failed in clinic. Here we used peptoid chemistry to develop ligands selective for Aβ42. Peptoids are N-substituted glycine oligomers, a class of peptidomimics. We synthesized an on-bead peptoid library consisting of 38,416 unique peptoids. The generated peptoid library was screened and ar ...[more]