Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC4103332 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Li Chaoran C Jiang Shan S Liu Si-Qi SQ Lykken Erik E Zhao Lin-tao LT Sevilla Jose J Zhu Bo B Li Qi-Jing QJ
Proceedings of the National Academy of Sciences of the United States of America 20140623 27
Forkhead box P3(+) (Foxp3(+)) regulatory T cells (Tregs) are crucial for peripheral tolerance. During inflammation, steady Foxp3 expression in Tregs is essential for maintaining their lineage identity and suppressive function. However, the molecular machinery governing Tregs' resilience to inflammation-induced Foxp3 destabilization remains elusive. Here, we demonstrate that methyl-CpG binding protein 2 (MeCP2), an eminent epigenetic regulator known primarily as the etiological factor of Rett syn ...[more]