MiR-9 promotes microglial activation by targeting MCPIP1.
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ABSTRACT:
SUBMITTER: Yao H
PROVIDER: S-EPMC4104446 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
MiR-9 promotes microglial activation by targeting MCPIP1.
Yao Honghong H Ma Rong R Yang Lu L Hu Guoku G Chen Xufeng X Duan Ming M Kook Yeonhee Y Niu Fang F Liao Ke K Fu Minggui M Hu Gang G Kolattukudy Pappachan P Buch Shilpa S
Nature communications 20140714
Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target ...[more]
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