Ontology highlight
ABSTRACT:
SUBMITTER: Pazos IM
PROVIDER: S-EPMC4104746 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Pazos Ileana M IM Ghosh Ayanjeet A Tucker Matthew J MJ Gai Feng F
Angewandte Chemie (International ed. in English) 20140430 24
The ability to quantify the local electrostatic environment of proteins and protein/peptide assemblies is key to gaining a microscopic understanding of many biological interactions and processes. Herein, we show that the ester carbonyl stretching vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methyl ester, is a convenient and sensitive probe in this regard, since its frequency correlates linearly with the local electrostatic field for both hydrogen ...[more]