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Smqnr variants in clinical isolates of Stenotrophomonas maltophilia in Brazil.

ABSTRACT: Stenotrophomonas maltophilia contains a novel chromosomally-encoded qnr gene named Smqnr that contributes to low intrinsic resistance to quinolone. We described Smqnr in 13 clinical isolates of S. maltophilia from two Brazilian hospitals, over a 2-year period. The strains were identified by API 20 NE (bioMérieux, France). Susceptibility by microdilution method to trimetroprim/sulfamethoxazole, ciprofloxacin, levofloxacin, minocycline, ceftazidime, chloramphenicol and ticarcillin/clavulanate was performed according to CLSI. PCR detection of Smqnr gene was carried out. The sequence of Smqnr was compared with those deposited in GenBank. Pulsed-field gel electrophoresis (PFGE) of all strains was performed. Thirteen Smqnr positives isolates were sequenced and three novel variants of Smqnr were identified. All 13 Smqnr isolates had distinguishable patterns by PFGE. This is the first report of Smqnr in S. maltophilia isolated in Brazil.

SUBMITTER: Gracia-Paez JI 

PROVIDER: S-EPMC4105090 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature

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Smqnr variants in clinical isolates of Stenotrophomonas maltophilia in Brazil.

Gracia-Paez Jorge Isaac JI   Ferraz Juliana Rosa JR   Silva Ivan Avelino França e IA   Rossi Flávia F   Levin Anna Sara AS   Costa Silvia Figueiredo SF  

Revista do Instituto de Medicina Tropical de Sao Paulo 20131101 6

Stenotrophomonas maltophilia contains a novel chromosomally-encoded qnr gene named Smqnr that contributes to low intrinsic resistance to quinolone. We described Smqnr in 13 clinical isolates of S. maltophilia from two Brazilian hospitals, over a 2-year period. The strains were identified by API 20 NE (bioMérieux, France). Susceptibility by microdilution method to trimetroprim/sulfamethoxazole, ciprofloxacin, levofloxacin, minocycline, ceftazidime, chloramphenicol and ticarcillin/clavulanate was  ...[more]

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