Ontology highlight
ABSTRACT:
SUBMITTER: Mojica MF
PROVIDER: S-EPMC5610502 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Mojica Maria F MF Papp-Wallace Krisztina M KM Taracila Magdalena A MA Barnes Melissa D MD Rutter Joseph D JD Jacobs Michael R MR LiPuma John J JJ Walsh Thomas J TJ Vila Alejandro J AJ Bonomo Robert A RA
Antimicrobial agents and chemotherapy 20170922 10
<i>Stenotrophomonas maltophilia</i> is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for <i>S. maltophilia</i> is urgent. We demonstrate the <i>in vitro</i> efficacy of aztreonam-avibactam (ATM-AVI) against <i>S. maltophilia</i> and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes ...[more]