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Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam.


ABSTRACT: Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 ?-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.

SUBMITTER: Mojica MF 

PROVIDER: S-EPMC5610502 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam.

Mojica Maria F MF   Papp-Wallace Krisztina M KM   Taracila Magdalena A MA   Barnes Melissa D MD   Rutter Joseph D JD   Jacobs Michael R MR   LiPuma John J JJ   Walsh Thomas J TJ   Vila Alejandro J AJ   Bonomo Robert A RA  

Antimicrobial agents and chemotherapy 20170922 10


<i>Stenotrophomonas maltophilia</i> is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for <i>S. maltophilia</i> is urgent. We demonstrate the <i>in vitro</i> efficacy of aztreonam-avibactam (ATM-AVI) against <i>S. maltophilia</i> and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes  ...[more]

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