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Transcriptional landscape of the prenatal human brain.


ABSTRACT: The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative and post-mitotic layers, wherein laminar signatures reflect cellular composition and developmental processes. Cytoarchitectural differences between human and mouse have molecular correlates, including species differences in gene expression in subplate, although surprisingly we find minimal differences between the inner and outer subventricular zones even though the outer zone is expanded in humans. Both germinal and post-mitotic cortical layers exhibit fronto-temporal gradients, with particular enrichment in the frontal lobe. Finally, many neurodevelopmental disorder and human-evolution-related genes show patterned expression, potentially underlying unique features of human cortical formation. These data provide a rich, freely-accessible resource for understanding human brain development.

SUBMITTER: Miller JA 

PROVIDER: S-EPMC4105188 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Transcriptional landscape of the prenatal human brain.

Miller Jeremy A JA   Ding Song-Lin SL   Sunkin Susan M SM   Smith Kimberly A KA   Ng Lydia L   Szafer Aaron A   Ebbert Amanda A   Riley Zackery L ZL   Royall Joshua J JJ   Aiona Kaylynn K   Arnold James M JM   Bennet Crissa C   Bertagnolli Darren D   Brouner Krissy K   Butler Stephanie S   Caldejon Shiella S   Carey Anita A   Cuhaciyan Christine C   Dalley Rachel A RA   Dee Nick N   Dolbeare Tim A TA   Facer Benjamin A C BA   Feng David D   Fliss Tim P TP   Gee Garrett G   Goldy Jeff J   Gourley Lindsey L   Gregor Benjamin W BW   Gu Guangyu G   Howard Robert E RE   Jochim Jayson M JM   Kuan Chihchau L CL   Lau Christopher C   Lee Chang-Kyu CK   Lee Felix F   Lemon Tracy A TA   Lesnar Phil P   McMurray Bergen B   Mastan Naveed N   Mosqueda Nerick N   Naluai-Cecchini Theresa T   Ngo Nhan-Kiet NK   Nyhus Julie J   Oldre Aaron A   Olson Eric E   Parente Jody J   Parker Patrick D PD   Parry Sheana E SE   Stevens Allison A   Pletikos Mihovil M   Reding Melissa M   Roll Kate K   Sandman David D   Sarreal Melaine M   Shapouri Sheila S   Shapovalova Nadiya V NV   Shen Elaine H EH   Sjoquist Nathan N   Slaughterbeck Clifford R CR   Smith Michael M   Sodt Andy J AJ   Williams Derric D   Zöllei Lilla L   Fischl Bruce B   Gerstein Mark B MB   Geschwind Daniel H DH   Glass Ian A IA   Hawrylycz Michael J MJ   Hevner Robert F RF   Huang Hao H   Jones Allan R AR   Knowles James A JA   Levitt Pat P   Phillips John W JW   Sestan Nenad N   Wohnoutka Paul P   Dang Chinh C   Bernard Amy A   Hohmann John G JG   Lein Ed S ES  

Nature 20140402 7495


The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative  ...[more]

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