The transcriptional landscape of age in human peripheral blood.
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ABSTRACT:
SUBMITTER: Peters MJ
PROVIDER: S-EPMC4639797 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
The transcriptional landscape of age in human peripheral blood.
Peters Marjolein J MJ Joehanes Roby R Pilling Luke C LC Schurmann Claudia C Conneely Karen N KN Powell Joseph J Reinmaa Eva E Sutphin George L GL Zhernakova Alexandra A Schramm Katharina K Wilson Yana A YA Kobes Sayuko S Tukiainen Taru T Ramos Yolande F YF Göring Harald H H HH Fornage Myriam M Liu Yongmei Y Gharib Sina A SA Stranger Barbara E BE De Jager Philip L PL Aviv Abraham A Levy Daniel D Murabito Joanne M JM Munson Peter J PJ Huan Tianxiao T Hofman Albert A Uitterlinden André G AG Rivadeneira Fernando F van Rooij Jeroen J Stolk Lisette L Broer Linda L Verbiest Michael M P J MM Jhamai Mila M Arp Pascal P Metspalu Andres A Tserel Liina L Milani Lili L Samani Nilesh J NJ Peterson Pärt P Kasela Silva S Codd Veryan V Peters Annette A Ward-Caviness Cavin K CK Herder Christian C Waldenberger Melanie M Roden Michael M Singmann Paula P Zeilinger Sonja S Illig Thomas T Homuth Georg G Grabe Hans-Jörgen HJ Völzke Henry H Steil Leif L Kocher Thomas T Murray Anna A Melzer David D Yaghootkar Hanieh H Bandinelli Stefania S Moses Eric K EK Kent Jack W JW Curran Joanne E JE Johnson Matthew P MP Williams-Blangero Sarah S Westra Harm-Jan HJ McRae Allan F AF Smith Jennifer A JA Kardia Sharon L R SL Hovatta Iiris I Perola Markus M Ripatti Samuli S Salomaa Veikko V Henders Anjali K AK Martin Nicholas G NG Smith Alicia K AK Mehta Divya D Binder Elisabeth B EB Nylocks K Maria KM Kennedy Elizabeth M EM Klengel Torsten T Ding Jingzhong J Suchy-Dicey Astrid M AM Enquobahrie Daniel A DA Brody Jennifer J Rotter Jerome I JI Chen Yii-Der I YD Houwing-Duistermaat Jeanine J Kloppenburg Margreet M Slagboom P Eline PE Helmer Quinta Q den Hollander Wouter W Bean Shannon S Raj Towfique T Bakhshi Noman N Wang Qiao Ping QP Oyston Lisa J LJ Psaty Bruce M BM Tracy Russell P RP Montgomery Grant W GW Turner Stephen T ST Blangero John J Meulenbelt Ingrid I Ressler Kerry J KJ Yang Jian J Franke Lude L Kettunen Johannes J Visscher Peter M PM Neely G Gregory GG Korstanje Ron R Hanson Robert L RL Prokisch Holger H Ferrucci Luigi L Esko Tonu T Teumer Alexander A van Meurs Joyce B J JB Johnson Andrew D AD
Nature communications 20151022
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for th ...[more]