Ontology highlight
ABSTRACT:
SUBMITTER: Hughes J
PROVIDER: S-EPMC4105944 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Hughes John J Hancock William O WO Fricks John J
Bulletin of mathematical biology 20111014 5
We develop a stochastic model for variable-length stepping of kinesins engineered with extended neck linkers. This requires that we consider the separation in microtubule binding sites between the heads of the motor at the beginning of a step. We show that this separation is stationary and can be included in the calculation of standard experimental quantities. We also develop a corresponding matrix computational framework for conducting computer experiments. Our matrix approach is more efficient ...[more]