Characterization of neonatal seizures in an animal model of hypoxic-ischemic encephalopathy.

ABSTRACT:

Objective

In this study, we use time-locked video and electroencephalography (EEG) recordings to characterize acute seizures and EEG abnormalities in an animal model that replicates many salient features of human neonatal hypoxic-ischemic encephalopathy (HIE) including the brain injury pattern and long-term neurologic outcome.

Methods

Hypoxia-ischemia (HI) was induced in 7-day-old rats by ligating the right carotid artery and exposing the pups to hypoxia for 2 h (Rice-Vannucci method). To identify seizures and abnormal EEG activity, pups were monitored by video-EEG during hypoxia and at various time points after HI. Occurrence of electroclinical seizures, purely electrographic seizures and other abnormal discharges on EEG, was quantified manually. A power spectrum analysis w

SUBMITTER: Sampath D 

PROVIDER: S-EPMC4107002 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature