Ontology highlight
ABSTRACT:
SUBMITTER: Magli A
PROVIDER: S-EPMC4107161 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Magli Alessandro A Schnettler Erin E Swanson Scott A SA Borges Luciene L Hoffman Kirsta K Stewart Ron R Thomson James A JA Keirstead Susan A SA Perlingeiro Rita C R RC
Stem cells (Dayton, Ohio) 20140801 8
Embryonic stem cells (ESCs) represent an ideal model to study how lineage decisions are established during embryonic development. Using a doxycycline-inducible mouse ESC line, we have previously shown that expression of the transcriptional activator Pax3 in early mesodermal cells leads to the robust generation of paraxial mesoderm progenitors that ultimately differentiate into skeletal muscle precursors. Here, we show that the ability of this transcription factor to induce the skeletal myogenic ...[more]