Ontology highlight
ABSTRACT:
SUBMITTER: Sidhu H
PROVIDER: S-EPMC4107404 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Sidhu Harpreet H Dansie Lorraine E LE Hickmott Peter W PW Ethell Douglas W DW Ethell Iryna M IM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140701 30
Fmr1 knock-out (ko) mice display key features of fragile X syndrome (FXS), including delayed dendritic spine maturation and FXS-associated behaviors, such as poor socialization, obsessive-compulsive behavior, and hyperactivity. Here we provide conclusive evidence that matrix metalloproteinase-9 (MMP-9) is necessary to the development of FXS-associated defects in Fmr1 ko mice. Genetic disruption of Mmp-9 rescued key aspects of Fmr1 deficiency, including dendritic spine abnormalities, abnormal mGl ...[more]