Ontology highlight
ABSTRACT:
SUBMITTER: Shao J
PROVIDER: S-EPMC4108195 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Journal of neuroimmunology 20121017 1-2
Neuroinflammation caused by microglial activation plays a key role in ischemia, neurodegeneration and many other CNS diseases. In this study, we found that Adjudin, a potential non-hormonal male contraceptive, exhibits additional function to reduce the production of proinflammatory mediators. Adjudin significantly inhibited LPS-induced IL-6 release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells. Furthermore, Adjudin exhibited anti-inflammatory properties by suppression of NF-κB p65 nu ...[more]