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Enzyme-directed assembly of a nanoparticle probe in tumor tissue.

ABSTRACT: Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

SUBMITTER: Chien MP

PROVIDER: S-EPMC4108424 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Enzyme-directed assembly of a nanoparticle probe in tumor tissue.

Chien Miao-Ping MP Thompson Matthew P MP Barback Christopher V CV Ku Ti-Hsuan TH Hall David J DJ Gianneschi Nathan C NC

Advanced materials (Deerfield Beach, Fla.) 20130528 26

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within t ...[more]

PMID: 23712821

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