Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC4109950 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Yang Jennifer J Bill Matthew A MA Young Gregory S GS La Perle Krista K Landesman Yosef Y Shacham Sharon S Kauffman Michael M Senapedis William W Kashyap Trinayan T Saint-Martin Jean-Richard JR Kendra Kari K Lesinski Gregory B GB
PloS one 20140724 7
XPO1/CRM1 is a key nuclear exporter protein that mediates translocation of numerous cellular regulatory proteins. We investigated whether XPO1 is a potential therapeutic target in melanoma using novel selective inhibitors of nuclear export (SINE). In vitro effects of SINE on cell growth and apoptosis were measured by MTS assay and flow cytometry [Annexin V/propidium iodide (PI)], respectively in human metastatic melanoma cell lines. Immunoblot analysis was used to measure nuclear localization of ...[more]