Ontology highlight
ABSTRACT:
SUBMITTER: De Cesare M
PROVIDER: S-EPMC4537003 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
De Cesare Michelandrea M Cominetti Denis D Doldi Valentina V Lopergolo Alessia A Deraco Marcello M Gandellini Paolo P Friedlander Sharon S Landesman Yosef Y Kauffman Michael G MG Shacham Sharon S Pennati Marzia M Zaffaroni Nadia N
Oncotarget 20150501 15
Survivin, which is highly expressed and promotes cell survival in diffuse malignant peritoneal mesothelioma (DMPM), exclusively relies on exportin 1 (XPO1/CRM1) to be shuttled into the cytoplasm and perform its anti-apoptotic function. Here, we explored the efficacy of Selective Inhibitors of Nuclear Export (SINE), KPT-251, KPT-276 and the orally available, clinical stage KPT-330 (selinexor), in DMPM preclinical models. Exposure to SINE induced dose-dependent inhibition of cell growth, cell cycl ...[more]