Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4110787 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Wang Xiaofang X Kimbrel Erin A EA Ijichi Kumiko K Paul Debayon D Lazorchak Adam S AS Chu Jianlin J Kouris Nicholas A NA Yavanian Gregory J GJ Lu Shi-Jiang SJ Pachter Joel S JS Crocker Stephen J SJ Lanza Robert R Xu Ren-He RH
Stem cell reports 20140606 1
Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive functions, indicating a potential therapy for MS, yet the variability and low potency of MSCs from adult sources hinder their therapeutic potential. MSCs derived from human embryonic stem cells (hES-MSCs) may be better suited for clinical treatment of MS because of their unlimited and stable supply. Here, we show that hES-MSCs significantly r ...[more]