Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC4110911 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20140604 15
A new series of fifteen 5-, 6-, and 8-appended 4-methylquinolines were synthesized and evaluated for their neural protective activities. Selected compounds were further examined for their inhibition of glycogen synthase kinase-3β (GSK-3β) and protein kinase C (PKC). Two most potent analogs, compounds 3 and 10, show nanomolar protective activities in amyloid β-induced MC65 cells and enzymatic inhibitory activities against GSK-3β, but poor PKC inhibitory activities. Using normal mouse model, the d ...[more]