Ontology highlight
ABSTRACT:
SUBMITTER: Ray A
PROVIDER: S-EPMC4111223 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Ray Aniruddha A Yoon Hyung Ki HK Koo Lee Yong Eun YE Kopelman Raoul R Wang Xueding X
The Analyst 20130601 11
Presented here is a novel method of in vivo pH sensing utilizing a hybrid optical imaging technique, photoacoustic imaging (PAI), and pH sensitive polymeric nanoprobes. Nanoprobes with hydrophobic core containing a pH sensitive dye were synthesized and used to measure the pH level ex vivo first and then in vivo by performing experiments on a rat joint model, with an achieved precision of less than 0.1 pH units. The ability of the hydrophobic functional groups in the polyacrylamide matrix to shie ...[more]